Conditions

Lipedema and Chronic Low-Grade Inflammation

Lipedema is a complex condition in which genetic predisposition, chronic low-grade inflammation, glycation, and microcirculatory dysfunction (the network of small blood vessels) contribute to the pathological accumulation of adipose tissue and the development of edema. Although genetic predisposition cannot be modified, it is possible to target the inflammatory mechanisms that drive disease progression. A personalized anti-inflammatory dietary approach, based on the results of the PerMè Recaller Program, helps identify individual food-related inflammatory triggers and reduce both the inflammatory and glycation burden. This represents a valuable nutritional support strategy in the management of lipedema and may contribute to improving patients' quality of life.
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Histamine Accumulation Syndrome: Causes, Symptoms, and the Correct Approach

Histamine accumulation syndrome is sometimes improperly referred to as “histamine intolerance.” Although this term is commonly used, it’s important to understand that it does not represent an intolerance in the classic sense (such as lactose intolerance, which is linked to a well-defined enzymatic deficiency, or gluten intolerance—both of which can be diagnosed with specific tests). So, let’s take a closer look at what it actually is.
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Depression, nutrition, and metabolism: understanding their connections and possible solutions.

Estimates indicate that more than 29 million Europeans live with depressive symptoms, and it is calculated that around 20% of the population will experience at least one depressive episode during their lifetime. These numbers continue to rise, fueled by factors related to stress, as well as changes in our lifestyles and eating habits. Depression is not just a psychological condition: it is also closely linked to the body, particularly metabolism and nutrition, which play a crucial role in both its onset and management.
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