{"id":21338,"date":"2025-04-29T16:51:42","date_gmt":"2025-04-29T15:51:42","guid":{"rendered":"https:\/\/www.geklab.com\/istamina\/"},"modified":"2025-05-27T14:11:31","modified_gmt":"2025-05-27T13:11:31","slug":"histamine","status":"publish","type":"post","link":"https:\/\/www.geklab.com\/en\/histamine\/","title":{"rendered":"Histamine Accumulation Syndrome: Causes, Symptoms, and the Correct Approach"},"content":{"rendered":"<div class=\"wp-block-stackable-icon-list stk-block-icon-list stk-block stk-5849285\" data-block-id=\"5849285\"><style>.stk-5849285{column-count:2 !important}.stk-5849285 ul li{list-style-image:url('data:image\/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCAxOTAgMTkwIiBzdHlsZT0iZmlsbDogIzAwMCAhaW1wb3J0YW50OyBjb2xvcjogIzAwMCAhaW1wb3J0YW50O3RyYW5zZm9ybTogcm90YXRlKGRlZykgIWltcG9ydGFudDsiPjxwb2x5Z29uIHBvaW50cz0iMTczLjgsMjguNCA2MC40LDE0MS44IDE1LjcsOTcuMiA1LjEsMTA3LjggNjAuNCwxNjMgMTg0LjQsMzkgMTczLjgsMjguNCIgZmlsbD0iIzAwMCIgc3Ryb2tlPSIjMDAwIiBzdHlsZT0iZmlsbDogcmdiKDAsIDAsIDApOyBzdHJva2U6IHJnYigwLCAwLCAwKTsiLz48L3N2Zz4=') !important}<\/style><ol><li><a href=\"#che\">What is histamine <\/a><\/li><li><a href=\"#causes\">Causes of Histamine Buildup<\/a><\/li><li><a href=\"#ruolo\">The role of nutrition <\/a><\/li><li><a href=\"#conclusioni\">Conclusions<\/a><\/li><\/ol><\/div><figure class=\"wp-block-image alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg\" alt=\"\" class=\"wp-image-21311\" style=\"width:561px;height:auto\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg 750w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-300x200.jpg 300w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-600x400.jpg 600w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure><p>Histamine accumulation syndrome is sometimes incorrectly referred to as \u201chistamine intolerance.\u201d Although the term is commonly used, it\u2019s important to understand that this is not an intolerance in the classic sense (such as <a href=\"https:\/\/www.geklab.com\/en\/lactose-intolerance-or-inflammation\/\">lactose intolerance<\/a>, which is linked to a well-defined enzyme deficiency, or <a href=\"https:\/\/www.geklab.com\/en\/celiac-disease-inflammation\/\">gluten intolerance<\/a>\u2014both of which can be diagnosed with specific tests). <\/p><p>Let\u2019s take a closer look at what it actually is.<\/p><p id=\"che\">When our body is inflamed, it may have difficulty properly metabolizing histamine, a substance found in various foods and naturally produced by the body. However, it\u2019s important to clarify that histamine is not always the main cause of the disorder, and that drastically eliminating histamine-containing foods is a debated topic\u2014one that may even be harmful to nutritional balance.<\/p><p><\/p><blockquote class=\"wp-block-stackable-blockquote stk-block-blockquote stk-block stk-a1fe2dd is-style-default\" data-v=\"2\" data-block-id=\"a1fe2dd\"><div class=\"has-text-align-left stk-block-blockquote__content stk-container stk-a1fe2dd-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks\"><div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-769b53b\" data-block-id=\"769b53b\"><style>.stk-769b53b .stk--svg-wrapper .stk--inner-svg svg:last-child{height:74px !important;width:74px !important}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-769b53b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-769-b-53-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-769-b-53-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 50 50\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M19.8 9.3C10.5 11.8 4.6 17 2.1 24.8c2.3-3.6 5.6-5.4 9.9-5.4 3.3 0 6 1.1 8.3 3.3 2.2 2.2 3.4 5 3.4 8.3 0 3.2-1.1 5.8-3.3 8-2.2 2.2-5.1 3.2-8.7 3.2-3.7 0-6.5-1.2-8.6-3.5C1 36.3 0 33.1 0 29 0 18.3 6.5 11.2 19.6 7.9l.2 1.4zm26.4 0C36.9 11.9 31 17 28.5 24.8c2.2-3.6 5.5-5.4 9.8-5.4 3.2 0 6 1.1 8.3 3.2 2.3 2.2 3.4 4.9 3.4 8.3 0 3.1-1.1 5.8-3.3 7.9-2.2 2.2-5.1 3.3-8.6 3.3-3.7 0-6.6-1.1-8.6-3.4-2.1-2.3-3.1-5.5-3.1-9.7 0-10.7 6.6-17.8 19.7-21.1l.1 1.4z\"><\/path><\/svg><\/div><\/span><\/div>\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-3aa8e15\" data-block-id=\"3aa8e15\"><style>.stk-3aa8e15 .stk-block-text__text{font-size:25px !important}@media screen and (max-width:1023px){.stk-3aa8e15 .stk-block-text__text{font-size:25px !important}}<\/style><p class=\"stk-block-text__text\"><strong><span style=\"color: var(--theme-palette-color-1, #088fa8);\" class=\"stk-highlight\">When our body is inflamed, it may have difficulty properly metabolizing histamine, a substance found in various foods and naturally produced by the body.<\/span><\/strong><\/p><\/div><\/div><\/div><\/blockquote><style>.kb-row-layout-id21338_03a1e3-05 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id21338_03a1e3-05 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id21338_03a1e3-05 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id21338_03a1e3-05 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id21338_03a1e3-05 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id21338_03a1e3-05 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id21338_03a1e3-05 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column21338_a3d7f6-22 > .kt-inside-inner-col,.kadence-column21338_a3d7f6-22 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column21338_a3d7f6-22 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column21338_a3d7f6-22{position:relative;}<\/style>\n<div class=\"wp-block-kadence-column kadence-column21338_a3d7f6-22 inner-column-1\"><div class=\"kt-inside-inner-col\"><div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-414fca6\" id=\"strong-what-is-histamine-strong\" data-block-id=\"414fca6\"><h2 class=\"stk-block-heading__text\"><strong>What is histamine?<\/strong><\/h2><\/div>\n\n<p id=\"cause\">Histamine is a molecule that plays a fundamental role in various physiological processes. It is mainly produced by immune system cells and is best known for its involvement in allergic and inflammatory reactions. For example, when the body comes into contact with an allergen, histamine is released in large amounts, causing typical symptoms such as itching, swelling, and redness.<\/p>\n\n<p>However, histamine is not only linked to <a href=\"https:\/\/www.geklab.com\/en\/hives-and-chronic-urticaria-causes-treatments\/\">allergies<\/a>\u2014it also performs important functions in the nervous system, where it acts as a neurotransmitter, influencing sleep, appetite, and body temperature regulation. In addition, histamine is involved in the regulation of stomach acid secretion, helping to stimulate the production of gastric juices.<\/p>\n\n<p id=\"cause\">Although it is a substance naturally present in the body, an excess of histamine\u2014often associated with ongoing inflammatory processes\u2014can lead to various disorders.<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>Causes of Histamine Buildup<\/strong><\/h2>\n\n<p>Excess histamine in the body can result from various factors, including a deficiency of the enzyme diamine oxidase (DAO), which is responsible for breaking it down in the intestines. But how is it possible that someone can consume histamine-rich foods for years without any issues and then suddenly develop symptoms? One possible explanation is the gradual accumulation of histamine associated with a state of <a href=\"https:\/\/www.geklab.com\/en\/all-due-to-inflammation\/\">systemic inflammation<\/a>, which may impair the body&#8217;s ability to eliminate it properly.<\/p>\n\n<p>Factors that may contribute to this situation include:<\/p>\n\n<ul class=\"wp-block-list\"><li>Intestinal disorders (<a href=\"https:\/\/www.geklab.com\/en\/irritable-bowel-syndrome-dietary-intervention\/\">irritable bowel syndrome,<\/a> Crohn\u2019s disease, celiac disease) <\/li>\n\n<li>Use of medications that alter gut flora (antibiotics, antiarrhythmics, painkillers, antihypertensives, antacids)<\/li>\n\n<li><a href=\"https:\/\/www.geklab.com\/en\/inflammation-from-sugars-and-glycation\/\">Excessive consumption of sugar, sweeteners, and alcohol<\/a><\/li>\n\n<li>Diet lacking in nutritional variety<\/li>\n\n<li>Stress and hormonal imbalances<\/li>\n\n<li>Alterations in gut microbiota, which affect histamine breakdown<\/li><\/ul>\n\n<p>All of these factors can easily create a pro-inflammatory environment that promotes the production of inflammatory cytokines and histamine itself. Inflammatory and allergic-like reactions are not only dependent on histamine but also on other cytokines involved in inflammatory processes. We are well aware that repetitive eating patterns, linked to excessive consumption, can be the cause of various inflammatory symptoms.&nbsp;<\/p>\n\n<p>Moreover, as we have seen, histamine is produced by the body and performs various essential functions for life itself, but it must also be properly metabolized and neutralized to avoid dangerous accumulation. DAO is the enzyme responsible for breaking down excess histamine, preventing undesirable effects.<\/p>\n\n<p>Symptoms related to excess histamine occur when the DAO enzyme can no longer neutralize it adequately. This may be due to an increase in histamine production, for example, in the presence of an inflammatory process. The most common symptoms include:<\/p>\n\n<ul class=\"wp-block-list\"><li>Intestinal issues (<a href=\"https:\/\/www.geklab.com\/en\/goodbye-bloated-belly\/\">bloating<\/a>, diarrhea, nausea, cramps, flatulence)<\/li>\n\n<li><a href=\"https:\/\/www.geklab.com\/en\/migraine-and-headache\/\">Headaches<\/a> and migraines<\/li>\n\n<li>Skin rashes, itching,<a href=\"https:\/\/www.geklab.com\/en\/hives-and-chronic-urticaria-causes-treatments\/\"> hives<\/a><\/li>\n\n<li>Respiratory issues, <a href=\"https:\/\/www.geklab.com\/en\/managing-asthma-and-seasonal-respiratory-allergies\/\">asthma<\/a>, rhinitis<\/li>\n\n<li>Tachycardia<\/li>\n\n<li>Worsening of allergic symptoms<\/li><\/ul>\n\n<p id=\"ruolo\">In some cases, excessive consumption of histamine-rich foods can worsen existing symptoms, especially in individuals with widespread inflammation or those who are allergic to other foods or environmental allergens.<\/p>\n\n<p><\/p>\n\n<h2 class=\"wp-block-heading\"><strong>The Role of Nutrition<\/strong><\/h2>\n\n<p>The amount of histamine present in food depends on many factors, including preparation methods, hygiene conditions, and fermentation duration. Some of the foods that contain the highest levels include:<\/p>\n\n<ul class=\"wp-block-list\"><li>Aged and blue cheeses<\/li>\n\n<li>Alcohol (especially champagne, red wine, and beer)<\/li>\n\n<li>Cured meats<\/li>\n\n<li>Canned tuna and smoked fish<\/li>\n\n<li>Sauerkraut, eggplants, tomatoes, spinach, and pineapple<\/li><\/ul>\n\n<p>Contrary to what one might think, completely eliminating these foods is not the ideal solution. As often happens with diets that exclude entire food groups, there is a risk of negatively affecting our immune responses to those foods in the long term.<\/p>\n\n<p>So, what should you do if you suspect a histamine overload?<br>It\u2019s better to adopt a personalized approach that helps lower inflammation levels and restores the body&#8217;s ability to eliminate excess histamine. In particular, it is useful to consider:<\/p>\n\n<ul class=\"wp-block-list\"><li>The body\u2019s overall inflammatory state and glycation processes can, in fact, worsen the situation. The <a href=\"https:\/\/www.geklab.com\/en\/perme-medical-program\/\">PerM\u00e8 Medical Program<\/a> can support the reduction of food- and sugar-related inflammatory responses, promote gut health, and improve clinical symptoms.<\/li>\n\n<li>The activity level of the DAO enzyme, which can be assessed through a specific blood test.<\/li>\n\n<li id=\"conclusioni\">Enzymatic support to help facilitate the metabolism of histamine.<\/li><\/ul>\n\n<h2 class=\"wp-block-heading\"><strong>Conclusion<\/strong>s<\/h2>\n\n<p>Histamine-related reactions are often just a manifestation of a broader issue: systemic inflammation. Rather than demonizing foods that are slightly higher in histamine and adopting overly restrictive diets, it is more effective to focus on reducing the body\u2019s overall inflammation levels. This can be achieved through a balanced and personalized diet, digestive enzyme support, and identifying the true causes of symptoms\u2014avoiding the mistake of unnecessarily excluding important (and often delicious) foods from your daily diet.<\/p>\n\n<p><em>Edited by <a href=\"https:\/\/www.geklab.com\/en\/the-scientific-editorial-team\/\">The scientific editorial Team GEK Lab<\/a><\/em><\/p>\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-11692d3\" id=\"articoli-correlati\" data-block-id=\"11692d3\"><style>.stk-11692d3{margin-bottom:10px !important}.stk-11692d3 .stk-block-heading__text{font-size:30px !important}@media screen and (max-width:1023px){.stk-11692d3 .stk-block-heading__text{font-size:30px !important}}<\/style><h3 class=\"stk-block-heading__text has-text-align-center\">Articoli correlati<\/h3><\/div>\n\n<div class=\"wp-block-uagb-post-grid uagb-post-grid  uagb-post__image-position-top uagb-post__image-enabled 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target=\"_self\" rel=\"bookmark noopener noreferrer\">Irritable bowel syndrome: dietary intervention<\/a>\n\t\t\t<\/h5>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\tThere are effective strategies for managing the symptoms of irritable bowel syndrome and inflamed intestines&#8230;.\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Histamine accumulation syndrome is sometimes improperly referred to as \u201chistamine intolerance.\u201d Although this term is commonly used, it\u2019s important to understand that it does not represent an intolerance in the classic sense (such as lactose intolerance, which is linked to a well-defined enzymatic deficiency, or gluten intolerance\u2014both of which can be diagnosed with specific tests).<\/p>\n<p>So, let\u2019s take a closer look at what it actually is.<\/p>\n","protected":false},"author":10,"featured_media":21312,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[305],"tags":[382,441,234,185,438,381,440,437,433,434,439,354,229,368,370],"class_list":["post-21338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conditions","tag-abdominal-bloating","tag-abdominal-pain","tag-asthma","tag-baff-en","tag-bowel","tag-gonfiore-addominale-en","tag-headaches","tag-histamine","tag-intestino-en","tag-istamina-en","tag-itches","tag-mal-di-testa-en","tag-metabolism","tag-orticaria-en","tag-urticaria"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":6}},"featured_image_urls":{"full":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg",750,500,false],"thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-150x150.jpg",150,150,true],"medium":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg",750,500,false],"large":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg",750,500,false],"1536x1536":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg",750,500,false],"2048x2048":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg",750,500,false],"xs-thumb":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-64x64.jpg",64,64,true],"woocommerce_archive_thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-300x400.jpg",300,400,true],"woocommerce_thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-300x400.jpg",300,400,true],"woocommerce_single":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-600x400.jpg",600,400,true],"woocommerce_gallery_thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4-64x64.jpg",50,50,true]},"post_excerpt_stackable":"<p>Histamine accumulation syndrome is sometimes improperly referred to as \u201chistamine intolerance.\u201d Although this term is commonly used, it\u2019s important to understand that it does not represent an intolerance in the classic sense (such as lactose intolerance, which is linked to a well-defined enzymatic deficiency, or gluten intolerance\u2014both of which can be diagnosed with specific tests).<\/p>\n<p>So, let\u2019s take a closer look at what it actually is.<\/p>\n","category_list":"<a href=\"https:\/\/www.geklab.com\/en\/category\/conditions\/\" rel=\"category tag\">Conditions<\/a>","author_info":{"name":"Eugenio Spagnolini","url":"https:\/\/www.geklab.com\/en\/author\/eugenio\/"},"comments_num":"0 comments","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Histamine Accumulation Syndrome: Causes, Symptoms, and the Correct Approach<\/title>\n<meta name=\"description\" content=\"Quando il nostro organismo \u00e8 infiammato, pu\u00f2 avere difficolt\u00e0 a metabolizzare correttamente l&#039;istamina, una sostanza presente in vari alimenti e prodotta naturalmente dal corpo. L&#039;accumulo di istamina nell&#039;organismo pu\u00f2 causare vari problemi.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.geklab.com\/en\/histamine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Histamine Accumulation Syndrome: Causes, Symptoms, and the Correct Approach\" \/>\n<meta property=\"og:description\" content=\"Il piede diabetico \u00e8 causato da anni di iperglicemia non controllata, che danneggia i vasi sanguigni e i nervi. La sofferenza dei nervi e dei vasi comincia molti anni prima che il diabete sia manifesto\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.geklab.com\/en\/histamine\/\" \/>\n<meta property=\"og:site_name\" content=\"GEK Lab\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/geklab.official\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-29T15:51:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-27T13:11:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Istamina-e-alimentazione_articleimage-4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"750\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Eugenio Spagnolini\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eugenio Spagnolini\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.geklab.com\/en\/histamine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.geklab.com\/en\/histamine\/\"},\"author\":{\"name\":\"Eugenio Spagnolini\",\"@id\":\"https:\/\/www.geklab.com\/#\/schema\/person\/e1adf7ed5f87cbfa6f7e001256e1dc5d\"},\"headline\":\"Histamine Accumulation Syndrome: Causes, Symptoms, and the Correct Approach\",\"datePublished\":\"2025-04-29T15:51:42+00:00\",\"dateModified\":\"2025-05-27T13:11:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.geklab.com\/en\/histamine\/\"},\"wordCount\":930,\"publisher\":{\"@id\":\"https:\/\/www.geklab.com\/#organization\"},\"keywords\":[\"abdominal bloating\",\"abdominal pain\",\"Asthma\",\"BAFF\",\"bowel\",\"Gonfiore addominale\",\"headaches\",\"histamine\",\"Intestino\",\"Istamina\",\"itches\",\"Mal di testa\",\"Metabolism\",\"Orticaria\",\"urticaria\"],\"articleSection\":[\"Conditions\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.geklab.com\/en\/histamine\/\",\"url\":\"https:\/\/www.geklab.com\/en\/histamine\/\",\"name\":\"Histamine Accumulation Syndrome: Causes, Symptoms, and the Correct Approach\",\"isPartOf\":{\"@id\":\"https:\/\/www.geklab.com\/#website\"},\"datePublished\":\"2025-04-29T15:51:42+00:00\",\"dateModified\":\"2025-05-27T13:11:31+00:00\",\"description\":\"Quando il nostro organismo \u00e8 infiammato, pu\u00f2 avere difficolt\u00e0 a metabolizzare correttamente l'istamina, una sostanza presente in vari alimenti e prodotta naturalmente dal corpo. 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