{"id":21237,"date":"2022-01-17T16:58:13","date_gmt":"2022-01-17T15:58:13","guid":{"rendered":"https:\/\/www.geklab.com\/predisposizione-genetica-tcf7l2-e-diabete-di-tipo-2\/"},"modified":"2025-05-27T16:32:23","modified_gmt":"2025-05-27T15:32:23","slug":"genetic-predisposition-tcf7l2-and-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/www.geklab.com\/en\/genetic-predisposition-tcf7l2-and-type-2-diabetes\/","title":{"rendered":"Genetic Predisposition: the TCF7L2 Gene and Type 2 Diabetes"},"content":{"rendered":"<figure class=\"wp-block-image alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"563\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg\" alt=\"\" class=\"wp-image-8568\" style=\"width:498px;height:auto\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg 850w, https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-600x397.jpg 600w, https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-300x199.jpg 300w, https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-768x509.jpg 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/figure><p>Nearly<strong> 4 million <\/strong>Italians are affected by t<strong>ype 2 diabetes<\/strong> (T2DM), and according to estimates from the Italian Society of Diabetology, another one and a half million are unaware they have it.<\/p><p>Diabetes is a <strong>chronic and insidious disease<\/strong> because it initially shows no symptoms, yet it is characterized by <strong>high levels of glucose<\/strong> in the blood, a condition known as<strong> hyperglycemia<\/strong>.<\/p><p>This condition can remain<strong> silent for a long time<\/strong> before suddenly worsening and leading to frequent cardiovascular, kidney, neurological, and eye complications.<\/p><p>The constant <strong>excess of sugar<\/strong> in the blood causes real tissue damage, also promoting the accumulation of<strong> free radicals<\/strong> and accelerating <strong>aging.<\/strong><\/p><p>This is why raising awareness and focusing on prevention is essential.<\/p><blockquote class=\"wp-block-stackable-blockquote stk-block-blockquote stk-block stk-8339d85 is-style-simple\" data-v=\"2\" data-block-id=\"8339d85\"><style>.stk-8339d85{margin-bottom:0px !important}<\/style><div class=\"has-text-align-left stk-block-blockquote__content stk-container stk-8339d85-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks\"><div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-3ce51f5\" data-block-id=\"3ce51f5\"><style>.stk-3ce51f5{left:-50px !important;position:absolute !important;opacity:0.2 !important}.stk-3ce51f5 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:100px !important;width:100px !important}.stk-3ce51f5 .stk--svg-wrapper .stk--inner-svg svg:last-child,.stk-3ce51f5 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g,path,rect,polygon,ellipse){fill:var(--theme-palette-color-1,#088fa8) !important}@media screen and (max-width:767px){.stk-3ce51f5{left:0px !important}}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-3ce51f5\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-3-ce-51-f-5-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-3-ce-51-f-5-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 50 50\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M22.3 30.5c0 6-4.8 10.8-10.8 10.8-2.3 0-4.5-.8-6.3-2-.9-.6-1.8-1.4-2.5-2.4-1.8-2.4-2.7-5.4-2.7-9 0-4.5 1.3-8.5 4-11.9 2.7-3.4 6.4-5.8 11.1-7.3v2.8c-2.7 2.2-4.4 5-4.9 8.3.4-.1.9-.1 1.3-.1 6-.1 10.8 4.8 10.8 10.8zm16.9-10.9c-.5 0-.9 0-1.3.1.5-3.3 2.2-6.1 4.9-8.3V8.7c-4.7 1.4-8.4 3.9-11.1 7.3-2.7 3.4-4 7.4-4 11.9 0 3.6.9 6.6 2.7 9 .8 1 1.6 1.8 2.5 2.4 1.8 1.3 3.9 2 6.3 2 6 0 10.8-4.8 10.8-10.8 0-6-4.8-10.9-10.8-10.9z\"><\/path><\/svg><\/div><\/span><\/div>\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-1c8d967\" data-block-id=\"1c8d967\"><style>.stk-1c8d967 .stk-block-text__text{font-size:25px !important}@media screen and (max-width:1023px){.stk-1c8d967 .stk-block-text__text{font-size:25px !important}}<\/style><p class=\"stk-block-text__text\"><strong><span style=\"color: var(--theme-palette-color-1, #088fa8);\" class=\"stk-highlight\">The presence of a specific variant in the TCF7L2 gene is associated with the development of type 2 diabetes.<\/span><\/strong><\/p><\/div><\/div><\/div><\/blockquote><div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div><style>.kadence-column21237_d264dc-62 > .kt-inside-inner-col,.kadence-column21237_d264dc-62 > .kt-inside-inner-col:before{border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}.kadence-column21237_d264dc-62 > .kt-inside-inner-col{background-color:#ebebeb;}.kadence-column21237_d264dc-62 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column21237_d264dc-62{position:relative;}<\/style>\n<div class=\"wp-block-kadence-column kadence-column21237_d264dc-62 kadence-column_33b0ff-ad\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-wrap.wp-block-kadence-rowlayout.kb-row-layout-id21237_0b794b-f2{margin-top:0px;margin-bottom:0px;}.kb-row-layout-id21237_0b794b-f2 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id21237_0b794b-f2 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id21237_0b794b-f2 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:0px;padding-bottom:10px;padding-left:250px;grid-template-columns:minmax(0, 80%) minmax(0, 20%);}.kb-row-layout-id21237_0b794b-f2{background-image:url('https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/02\/copertinaslide-glyco-1.png');background-size:contain;background-position:3% 100%;background-attachment:scroll;background-repeat:no-repeat;}.kb-row-layout-id21237_0b794b-f2 > .kt-row-layout-overlay{opacity:0.30;}.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep{height:100px;}.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep svg{width:100%;}.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep svg{fill:#ffffff!important;}@media all and (max-width: 1024px){.kb-row-layout-id21237_0b794b-f2 > .kt-row-column-wrap{padding-right:0px;padding-left:45px;grid-template-columns:minmax(0, 2fr) minmax(0, 1fr);}}@media all and (max-width: 1024px){.kb-row-layout-id21237_0b794b-f2{background-image:none !important;}}@media all and (max-width: 1024px){.kb-row-layout-id21237_0b794b-f2 [id*=\"jarallax-container-\"]{display:none !important;}}@media all and (max-width: 1024px){.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep{height:px;}}@media all and (max-width: 1024px){.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep svg{width:%;}}@media all and (max-width: 767px){.kb-row-layout-id21237_0b794b-f2 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-none, 0 );row-gap:var(--global-kb-gap-none, 0 );padding-top:30px;padding-right:20px;padding-bottom:20px;padding-left:20px;grid-template-columns:minmax(0, 1fr);}.kb-row-layout-wrap.wp-block-kadence-rowlayout.kb-row-layout-id21237_0b794b-f2{background-image:none !important;}.kb-row-layout-id21237_0b794b-f2 [id*=\"jarallax-container-\"]{display:none !important;}.kb-row-layout-id21237_0b794b-f2 > .kt-row-layout-overlay{opacity:0.30;background-image:url('https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/09\/copertina.png');background-size:contain;background-position:right bottom;background-attachment:fixed;background-repeat:no-repeat;}.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep{height:px;}.kb-row-layout-id21237_0b794b-f2 .kt-row-layout-bottom-sep svg{width:%;}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id21237_0b794b-f2 alignnone kt-row-has-bg wp-block-kadence-rowlayout\"><div class=\"kt-row-layout-overlay kt-row-overlay-normal\"><\/div><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-left-golden kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column21237_f3544b-67 > .kt-inside-inner-col,.kadence-column21237_f3544b-67 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column21237_f3544b-67 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column21237_f3544b-67{position:relative;}@media all and (max-width: 767px){.kadence-column21237_f3544b-67{text-align:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column21237_f3544b-67 inner-column-1\"><div class=\"kt-inside-inner-col\"><div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-stackable-image stk-block-image has-text-align-left has-text-align-center-mobile stk-block stk-08fb2a7 alignleft\" data-block-id=\"08fb2a7\"><style>.stk-08fb2a7 .stk-img-wrapper{height:50px !important}.stk-08fb2a7 .stk-img-wrapper img{object-position:0% 50% !important;object-fit:contain !important}@media screen and (max-width:767px){.stk-08fb2a7{padding-right:60px !important;padding-left:60px !important}.stk-08fb2a7 .stk-img-wrapper img{object-fit:contain !important}}<\/style><a class=\"stk-link\" href=\"\/perme-test\/\"><div class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-19762\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/Glyco_medical_program.webp\" width=\"1451\" height=\"418\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/Glyco_medical_program.webp 1451w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/Glyco_medical_program-300x86.webp 300w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/Glyco_medical_program-1024x295.webp 1024w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/Glyco_medical_program-768x221.webp 768w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/Glyco_medical_program-600x173.webp 600w\" sizes=\"auto, (max-width: 1451px) 100vw, 1451px\" \/><\/div><\/a><\/div>\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p>Determine your genetic predispositions related to sugar consumption with the <strong>Glyco Medical Program.<\/strong><\/p><\/div><\/div>\n\n<style>.kadence-column21237_4636b9-fc > .kt-inside-inner-col,.kadence-column21237_4636b9-fc > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column21237_4636b9-fc > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column21237_4636b9-fc{text-align:center;}.kadence-column21237_4636b9-fc{position:relative;}<\/style>\n<div class=\"wp-block-kadence-column kadence-column21237_4636b9-fc\"><div class=\"kt-inside-inner-col\"><div class=\"wp-block-stackable-image stk-block-image has-text-align-center stk-block stk-515b74c\" data-block-id=\"515b74c\"><style>.stk-515b74c{margin-bottom:0px !important}.stk-515b74c .stk-img-wrapper{width:150px !important}<\/style><figure><div class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-19887\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-scaled.webp\" width=\"2560\" height=\"2560\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-scaled.webp 2560w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-300x300.webp 300w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-1024x1024.webp 1024w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-150x150.webp 150w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-768x768.webp 768w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-1536x1536.webp 1536w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-2048x2048.webp 2048w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-64x64.webp 64w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-600x600.webp 600w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/02\/glyco-ita-100x100.webp 100w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/div><\/figure><\/div>\n\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-f73d24c\" data-block-id=\"f73d24c\"><style>.stk-f73d24c{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important}<\/style><div class=\"stk-row stk-inner-blocks has-text-align-center stk-block-content stk-button-group\"><div class=\"wp-block-stackable-button stk-block-button has-text-align-center stk-block stk-7fe5a84\" data-block-id=\"7fe5a84\"><style>.stk-7fe5a84{margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.geklab.com\/en\/glyco-medical-program\/\"><span class=\"stk-button__inner-text\">Find out more<\/span><\/a><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><style>.kb-row-layout-id21237_f11879-2d > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id21237_f11879-2d > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id21237_f11879-2d > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:0px;padding-bottom:0px;grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id21237_f11879-2d > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id21237_f11879-2d > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id21237_f11879-2d > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id21237_f11879-2d alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column21237_b36e8f-37 > .kt-inside-inner-col,.kadence-column21237_b36e8f-37 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column21237_b36e8f-37 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column21237_b36e8f-37{position:relative;}<\/style>\n<div class=\"wp-block-kadence-column kadence-column21237_b36e8f-37 inner-column-1\"><div class=\"kt-inside-inner-col\"><p>In the past, one could only guess at a genetic predisposition to certain conditions based on family stories. Today, it is possible to concretely measure whether a <strong>genetic predisposition<\/strong> has been inherited through a laboratory test.<\/p>\n\n<p>Among the many genes consistently associated with T2DM, one of the strongest associations is linked to the <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17476472\/\">presence or absence of a variant in the TCF7L2 gene<\/a>. The mechanisms by which this gene can influence the pathogenesis of diabetes are also well understood.<\/p>\n\n<p>The presence of a specific variant in the TCF7L2 gene is <strong>associated with the development of type 2 diabetes<\/strong>. It indicates an <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17476472\/\">increased risk of developing the disease\u2014approximately twice <\/a>as high compared to individuals who do not carry this specific variant.<\/p>\n\n<p>Fortunately, the information contained within DNA is, in most cases, not \u201cimmutable\u201d and does not \u201cpredetermine\u201d a person\u2019s fate. Multiple environmental factors can influence and even mitigate genetic predispositions, including those that are considered \u201cunfavorable.\u201d<\/p>\n\n<p>Knowing that you have inherited an unfavorable <strong>genetic predisposition<\/strong> could, in itself, be the motivation to change attitude or lifestyle. One should, therefore, try to gain an advantage from knowledge or events that, if given a choice, we would have preferred to avoid.<\/p>\n\n<p>The <a href=\"https:\/\/www.geklab.com\/en\/perme-medical-program\/\">PerM\u00e8 Medical Program<\/a>, the <a href=\"https:\/\/www.geklab.com\/en\/glyco-medical-program\/\">Glyco Medical Program<\/a>, and the <a href=\"https:\/\/www.geklab.com\/en\/screening\/\">screenings<\/a> allow for the analysis of potential genetic predisposition to the<strong> development of type 2 diabetes.<\/strong><\/p>\n\n<div class=\"taxonomy-post_tag wp-block-post-terms\"><a href=\"https:\/\/www.geklab.com\/en\/tag\/diabetes\/\" rel=\"tag\">Diabetes<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/glycation\/\" rel=\"tag\">Glycation<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/glycemia\/\" rel=\"tag\">glycemia<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/glyco-medical-program\/\" rel=\"tag\">Glyco Medical Program<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/mgo-en\/\" rel=\"tag\">MGO<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/perme-medical-program\/\" rel=\"tag\">PerM\u00e8 Medical Program<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/sugar\/\" rel=\"tag\">Sugar<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.geklab.com\/en\/tag\/tcf7l2-en\/\" rel=\"tag\">TCF7L2<\/a><\/div><\/div><\/div>\n<\/div><\/div><p><em>Edited by <a href=\"https:\/\/www.geklab.com\/en\/the-scientific-editorial-team\/\">The scientific editorial Team GEK Lab <\/a><\/em><\/p><div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-11692d3\" id=\"articoli-correlati\" data-block-id=\"11692d3\"><style>.stk-11692d3{margin-bottom:10px !important}.stk-11692d3 .stk-block-heading__text{font-size:30px !important}@media screen and (max-width:1023px){.stk-11692d3 .stk-block-heading__text{font-size:30px !important}}<\/style><h3 class=\"stk-block-heading__text has-text-align-center\">Articoli correlati<\/h3><\/div><div class=\"wp-block-uagb-post-grid uagb-post-grid  uagb-post__image-position-top uagb-post__image-enabled uagb-block-ea6d35cb     uagb-post__items uagb-post__columns-3 is-grid uagb-post__columns-tablet-2 uagb-post__columns-mobile-1 uagb-post__equal-height\" data-total=\"4\" style=\"\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.geklab.com\/en\/diabetic-foot\/\" target=\"_self\" rel=\"bookmark noopener noreferrer\" class='uagb-image-ratio-inherit'><img loading=\"lazy\" decoding=\"async\" width=\"755\" height=\"500\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Predisposizione-genetica-al-diabete-conoscerla-per-fare-in-anticipo-le-mosse-giuste_articleimage-4.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Predisposizione-genetica-al-diabete-conoscerla-per-fare-in-anticipo-le-mosse-giuste_articleimage-4.jpg 755w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Predisposizione-genetica-al-diabete-conoscerla-per-fare-in-anticipo-le-mosse-giuste_articleimage-4-300x199.jpg 300w, https:\/\/www.geklab.com\/wp-content\/uploads\/2025\/04\/Predisposizione-genetica-al-diabete-conoscerla-per-fare-in-anticipo-le-mosse-giuste_articleimage-4-600x397.jpg 600w\" sizes=\"auto, (max-width: 755px) 100vw, 755px\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h5 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/www.geklab.com\/en\/diabetic-foot\/\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Diabetic foot: when diabetes has taken too much of a foothold<\/a>\n\t\t\t<\/h5>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\tDiabetic foot is one of the most common chronic complications of diabetes mellitus. It involves&#8230;\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.geklab.com\/en\/ozempic-easy-weight-loss-everything-you-need-to-know\/\" target=\"_self\" rel=\"bookmark noopener noreferrer\" class='uagb-image-ratio-inherit'><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/06\/Ozempic_rimedio_per_dimagrire-1685852726743.jpeg-l_ozempic__rimedio_per_dimagrire.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/06\/Ozempic_rimedio_per_dimagrire-1685852726743.jpeg-l_ozempic__rimedio_per_dimagrire.jpg 600w, https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/06\/Ozempic_rimedio_per_dimagrire-1685852726743.jpeg-l_ozempic__rimedio_per_dimagrire-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h5 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/www.geklab.com\/en\/ozempic-easy-weight-loss-everything-you-need-to-know\/\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Easy weight loss with Ozempic? Here\u2019s everything you need to know<\/a>\n\t\t\t<\/h5>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\tOzempic is the brand name of the injectable drug based on semaglutide, originally developed for&#8230;\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.geklab.com\/en\/cardiovascular-diseases-the-role-of-low-grade-inflammation\/\" target=\"_self\" rel=\"bookmark noopener noreferrer\" class='uagb-image-ratio-inherit'><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/01\/Malattie-cardiovascolari-e-rischio-cardiaco-e-se-i-grassi-non-c-entrassero-nulla_articleimage-4.jpg\" class=\"attachment-large size-large\" alt=\"malattie cardiovascolari\" srcset=\"https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/01\/Malattie-cardiovascolari-e-rischio-cardiaco-e-se-i-grassi-non-c-entrassero-nulla_articleimage-4.jpg 750w, https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/01\/Malattie-cardiovascolari-e-rischio-cardiaco-e-se-i-grassi-non-c-entrassero-nulla_articleimage-4-300x200.jpg 300w, https:\/\/www.geklab.com\/wp-content\/uploads\/2024\/01\/Malattie-cardiovascolari-e-rischio-cardiaco-e-se-i-grassi-non-c-entrassero-nulla_articleimage-4-600x400.jpg 600w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h5 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/www.geklab.com\/en\/cardiovascular-diseases-the-role-of-low-grade-inflammation\/\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Cardiovascular diseases: the role of low-grade inflammation<\/a>\n\t\t\t<\/h5>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\tThe term &#8220;low-grade inflammation&#8221; may sound somewhat reassuring, but it&#8217;s actually a key concept that&#8230;\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Assessing whether one has a genetic predisposition to type 2 diabetes allows for the implementation of dietary and supplement strategies with a preventive focus.<\/p>\n","protected":false},"author":2,"featured_media":8569,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[304],"tags":[206,191,391,192,223,211,250,413],"class_list":["post-21237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-insights","tag-diabetes","tag-glycation","tag-glycemia","tag-glyco-medical-program","tag-mgo-en","tag-perme-medical-program","tag-sugar","tag-tcf7l2-en"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":6}},"featured_image_urls":{"full":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg",850,563,false],"thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-150x150.jpg",150,150,true],"medium":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-300x199.jpg",300,199,true],"medium_large":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-768x509.jpg",768,509,true],"large":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg",850,563,false],"1536x1536":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg",850,563,false],"2048x2048":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg",850,563,false],"xs-thumb":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s.jpg",64,42,false],"woocommerce_archive_thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-300x400.jpg",300,400,true],"woocommerce_thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-300x400.jpg",300,400,true],"woocommerce_single":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-600x397.jpg",600,397,true],"woocommerce_gallery_thumbnail":["https:\/\/www.geklab.com\/wp-content\/uploads\/2022\/01\/65940223_s-100x100.jpg",50,50,true]},"post_excerpt_stackable":"<p>Assessing whether one has a genetic predisposition to type 2 diabetes allows for the implementation of dietary and supplement strategies with a preventive focus.<\/p>\n","category_list":"<a href=\"https:\/\/www.geklab.com\/en\/category\/scientific-insights\/\" rel=\"category tag\">Scientific Insights<\/a>","author_info":{"name":"Marcello Granata","url":"https:\/\/www.geklab.com\/en\/author\/marcello\/"},"comments_num":"0 comments","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Genetic Predisposition: the TCF7L2 Gene and Type 2 Diabetes<\/title>\n<meta name=\"description\" content=\"Conoscere se si ha una predisposizione genetica per il diabete di tipo 2 consente di mettere in atto le strategie preventive pi\u00f9 adatte.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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